Researchers found that lowering MHC I can expose cancerous or foreign cells to CD4+ T cell attack, reshaping assumptions ...

For decades, cancer immunotherapy has focused primarily on CD8 + cytotoxic T lymphocytes as the main executors of tumor cell killing. However, growing clinical and single-cell sequencing evidence ...

In the fight against cancer, immunotherapy—which aims to boost the body's natural defenses against cancer—is experiencing remarkable growth. Most of these treatments are based on CD8 T lymphocytes, ...

"Vaccine strategies have focused on inducing inflammatory CD4 T cells, but it might be time to shift our focus to reducing inflammation to the minimum level needed to limit growth of the bacteria, ...

Persistent viral infections pose a unique challenge to the immune system. Prolonged antigen exposure drives T cells into a state of exhaustion — a ...

Researchers at Karolinska Institutet have identified new properties of CD4-positive T cells in the human intestines and liver ...

The decrease in CD4 cells during HIV infection seems to be driven by immune activation, which does not always correlate with viral load. Experienced clinicians are all too familiar with the ...

For decades, HIV treatment has depended on one hard truth: once medication stops, the virus usually comes roaring back. Modern antiretroviral drugs can suppress HIV so effectively that many people ...

In patients with autoimmune hemolytic anemia (AIHA), the risk of relapse is high owing to persistent autoreactive B-cell activity. Multirefractory AIHA is a more advanced stage of disease that is ...