Despite spanning about three billion base pairs, the human genome is wrapped up tight in a highly organized fashion in the nucleus. This coordinated structure, in part, enables the cell to regulate ...

Researchers at The University of Texas MD Anderson Cancer Center have developed a new computational approach designed to better account for changes in gene expression within tumors relative to their ...

To further the quantitative understanding of cellular decision making, Dr. Gregory Reeves and his team in the chemical engineering department have worked to interpret how a transcription factor ...

A fleeting DNA fold called i‑DNA can switch cancer‑related genes on and off, revealing a hidden structural weak point that ...

Human DNA constantly refolds in 3D space, and these looping dynamics regulate gene expression and cell identity.

A caffeine-triggered switch that turns CRISPR gene editing on and off inside cells could one day improve cancer therapy.

In the early 20th century, Paul Ehrlich coined the term “magic bullet” to describe a therapy that could selectively eliminate disease without harming healthy tissues. A century later, Ehrlich's vision ...

Gene expression testing, such as Oncotype DX, aids in chemotherapy decisions for hormone receptor-positive breast cancer, though challenges exist for premenopausal patients with scores under 25.

DNA can also be demethylated, either through passive or active processes. Passive DNA demethylation occurs when the methylation pattern is not replenished during DNA replication and gradually ...

Researchers at The University of Texas MD Anderson Cancer Center have developed a new computational approach designed to ...