The Nature Index 2025 Research Leaders — previously known as Annual Tables — reveal the leading institutions and countries/territories in the natural and health sciences, according to their output in ...
Cullgen (Shanghai) Inc. has disclosed proteolysis targeting chimera (PROTAC) compounds comprising a DDB1- and CUL4-associated factor 1 (DCAF1) binding moiety covalently linked to target protein moiety ...
The DDB1–DCAF1–Vpr–UNG2 crystal structure reveals how HIV-1 Vpr steers human UNG2 toward destruction
Lentiviral genomes encode Gag, Pol and Env proteins along with six accessory proteins 1, which facilitate virus replication in vivo 2,3. The accessory viral protein R (Vpr), a 14-kDa protein, is ...
Initially, the DDB1 and CUL4 Associated Factor 1 (DCAF1) was identified as a protein that interacts with human immunodeficiency virus 1 (HIV-1) virion-associated protein (Vpr) and regulates cell ...
Kymera Therapeutics Inc. has synthesized proteolysis targeting chimera (PROTAC) compounds comprising a DDB1- and CUL4-associated factor 1 (DCAF1) binding moiety covalently linked to a ...
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