In this video, Arc Institute Postdoctoral Fellow Vincent Tran walks through MULTI-evolve, an AI-guided framework that compresses protein engineering from months of iterative experimentation into weeks ...

The search space for protein engineering grows exponentially with complexity. A protein of just 100 amino acids has 20100 possible variants—more combinations than atoms in the observable universe.

Directed Evolution (DE) is a method developed by Nobel laureate Frances Arnold to improve protein fitness for specific applications. However, DE can be less efficient when mutations show epistatic ...

The world of protein engineering just took a giant leap forward. A team in China has developed a method that makes designing better proteins faster, cheaper, and easier. Led by Professor Gao Caixia ...

Today, the Royal Swedish Academy announced the winners of this year’s Nobel prize for Chemistry: one half goes to Prof. Frances Arnold from the California Institute for Technology, the other half to ...

The Molecular Evolution, Protein Engineering, and Production (MEPEP) Facility, part of the Purdue Institute of Inflammation, Immunology and Infectious Disease (PI4D), is a new discovery resource ...

An artist’s depiction of an artificially evolved enzyme breaking a silicon-carbon bond. [Caltech/Dow] For the first time, scientists have engineered an enzyme that can break the stubborn man-made ...

Their overview highlights innovative methods based on B-factor analysis, ancestral sequence reconstruction (ASR), and machine learning (ML), providing tools to design enzymes that withstand high ...