Mammalian immunity has long been thought to rely solely on proteins and specialized immune cells. However, a newly proposed concept—RNA immunity—is reshaping this perspective. In a recent publication ...

Despite the remarkable clinical efficacy of chimeric antigen receptor (CAR) T cells in hematological malignancies, only a subset of patients achieve a durable complete response. Furthermore, ...

(Upper left) Chemotherapy promotes CAR-T cell infiltration by enhancing chemokine secretion or degrading the ECM. (Upper right) Radiotherapy promotes CAR-T cell infiltration by improving vascular ...

The innate immune system serves as the body's first line of defence, rapidly detecting and responding to external pathogens and internal damage. Recent advances in the field have highlighted the ...

Itaconate, an endogenous mitochondrial metabolite produced by the enzyme aconitate decarboxylase 1 (ACOD1), has emerged as a central regulator of ...