Scientists have, for the first time, mapped in exquisite three-dimensional detail six major conformations of a membrane in ...

Ion channels are specialised membrane proteins that govern the selective passage of ions across biological membranes, thereby underpinning electrical signalling, osmotic balance and various cellular ...

Lysosomes are the recycling centers of human cells. Larger molecules are broken down inside the membrane-enclosed vesicles. Malfunctions can lead to neurodegenerative diseases such as Parkinson's.

A group of Chinese researchers has conducted a mouse study to determine the role of Orai1, a membrane calcium-selective ion channel protein, in pancreatitis-associated acute lung injury. Mice without ...

Microglia, the immune cells that protect the brain, are thought to maintain a healthy brain environment by removing unwanted substances through dynamic remodeling of the actin cytoskeleton, the cell's ...

The design of new calcium channels, built bottom-up from scratch, was reported last week in Nature. "Biochemists have been studying ion channels for decades and debating about how they work for almost ...

A new study has rewritten the conventionally understood evolutionary history of certain ion channels -- proteins critical for electrical signaling in the nervous system. The study shows that the ...

Discovery could provide a blueprint for improved treatment of stroke This cryo-EM structure of acid-sensing ion channel 1a, ...

Researchers decipher the function of an ion channel involved in cellular degradation processes and create new possibilities for Parkinson’s therapies. Washbowls, bathtubs, and sinks are all fitted ...