High-risk constitutional MLH1 methylation underlies a significant proportion of early-onset endometrial cancers and colorectal cancers with tumor MLH1 methylation. At the American Society of Clinical ...

PATIENTS AND METHODS: Clinical and pathologic data were collected from 138 families with HNPCC. Mutation analyses were performed for all families. Survival analysis was used to calculate the ...

Cancers are predominantly characterized by their genomic aberrations, but over the past decades, there has also been an increasing focus on epigenetic alterations in cancer biology. 12-15 Although ...

Genotype-informed surveillance should pair colonoscopy with upper endoscopy when MLH1/MSH2 mutations or family history ...