Recent research has observed that chemical modifications called phosphorylation of various proteins *1) in brain neurons dynamically regulates in controlling sleep and wakefulness. On the other hand, ...

Addition and removal of ubiquitin or ubiquitin chains to and from proteins is a tightly regulated process that contributes to cellular signaling and protein stability. Here we show that ...

Through its job of adding phosphate groups to target proteins, the kinase Akt is involved in regulating cell proliferation (and, therefore, cancer), glucose metabolism, and transcription, among many ...

Mathematical modeling helps researchers to understand how enzymes in the body work to ensure normal functioning. The models also can show how genetic mutations alter the enzymes' behavior in ways that ...

A pioneering study has revealed how cellular compartments (organelles) are able to control how much they interact and cooperate. A pioneering study has revealed how cellular compartments (organelles) ...

Researchers at the University of Dundee have identified an enzyme that inhibits the protein kinase product of a gene known as LRRK2, mutations in which are the common genetic cause of Parkinson’s ...

Everything a cell does, from dividing in two to migrating to a different part of the body, is controlled by enzymes that chemically modify other proteins in the cell. Researchers at Princeton ...