Hierarchical structure of muscle and activation of thin filaments. In both skeletal and cardiac muscles under a relaxed state, a low intracellular calcium ion concentration is maintained and the ...

New research has identified the specific biological mechanism behind the muscle dysfunction found in myotonic dystrophy type 1 (DM1) and further shows that calcium channel blockers can reverse these ...

Johns Hopkins Medicine researchers discover that blocking the ion channel called TRPC6 in genetically modified mice with severe or moderate Duchenne muscular dystrophy (DMD) substantially improves ...