The thymus is the central organ for T lymphocyte generation and self‐tolerance. Within its cortex and medulla, thymic epithelial cells (TECs) present peptide–major histocompatibility complexes that ...

The immune system has evolved to mount immune responses against foreign pathogens and to remain silent against self-antigens. A balance between immunity and tolerance is required as any disturbance ...

'Peacemaker' immune cells could help treat diseases ranging from type 1 diabetes to neurodegeneration by restoring immune tolerance, according to a new paper in Frontiers in Science. From cancer, ...

The 2025 Nobel Prize in Physiology or Medicine was awarded earlier this month to immunologists Mary E. Brunkow (Institute for Systems Biology, Seattle), Fred Ramsdell (Sonoma Biotherapeutics, San ...

The Nobel-prize season always kicks off with the award for physiology or medicine, which highlights work in fields such as genetics, cell biology and evolution. This year’s award went to three ...

Scientists from the Institute of Molecular Genetics of the Czech Academy of Sciences, in collaboration with the Faculty of Science at Charles University, have uncovered a completely new role for the ...

Findings from a new study led by scientists at Stanford University School of Medicine and their colleagues elsewhere show that a single signaling pathway controls whether immune cells attack or ...

Autoimmune diseases stem from a complicated interplay of immune dysregulation, characterized by chronic inflammation and the loss of self-tolerance. Cytokines are central to these processes. These ...

Cancer immunotherapy has revolutionized oncology, with immune checkpoint inhibitors (ICIs) becoming integral components of modern anti-cancer treatment ...