Many of the proteins that calmodulin binds are unable to bind calcium themselves, and use calmodulin as a calcium sensor and signal transducer. Calmodulin can also make use of the calcium stores in …

More than 300 calmodulin-binding proteins (calmodulin targets) have been identified to date (representative examples are summarized in Fig. 1). Among these, calmodulin-dependent enzymes …

Calmodulin acts as an intermediary protein that senses calcium levels and relays signals to various calcium-sensitive enzymes, ion channels and other proteins. Calmodulin is a small dumbbell-shaped …

Calmodulin is a protein that binds to the intracellular face of GPCRs, such as the μ-opioid receptor, and helps in reducing GPCR signaling by affecting G-protein coupling.

Apr 6, 2025 · Calmodulin (CaM) is a calcium-modulated protein that plays a crucial role in mediating the effects of calcium ions in living systems. It is a calcium-binding protein found in the cytoplasm of all …

Jul 1, 2011 · We studied the reorientation of the two major domains of calmodulin and the flexibility of the tether. The simulations shed light on the time-dependent availability of various target-specific …

Sep 9, 2024 · Calmodulin, a protein critically important for the regulation of all major cardiac ion channels, is the quintessential cellular calcium sensor and plays a key role in preserving cardiac …

Aug 1, 2000 · Calmodulin is the best studied and prototypical example of the E–F-hand family of Ca2+-sensing proteins. Changes in intracellular Ca2+ concentration regulate calmodulin in three distinct …

Calmodulin is a ubiquitous, highly conserved protein that plays a critical role in numerous essential cellular functions, including Ca 2+ transport, cell motility, cytoskeletal assembly, protein …

Calmodulin belongs to a family of proteins along with troponin C, another essential calcium-binding protein involved in muscle contraction. Calmodulin is an essential protein; mutations in any of the …