Individuals with different genotypes are affected differently by exposure to the same environmental factors, and thus gene–environment interactions can result in different disease phenotypes.

2 days ago · Gene–environment interaction refers to the interplay of genes (and, more broadly, genome function) and the physical and social environment. These interactions influence the …

Jan 28, 2026 · A large cross-population atlas of gene–environment interactions reveals how age, sex and lifestyle shape genetic effects, heritability, prediction accuracy and disease biology, with...

Often, genetic and environmental factors contribute to a given disease or phenotype in a non-additive manner, yielding a gene–environment (G × E) interaction. In this work, we broadly review current …

Jun 17, 2025 · A gene-environment interaction (GxE) occurs when the effect of a gene on a trait or outcome is dependent on the environmental context, or, conversely, when the impact of an …

Gene–environment interactions occur when genetic factors affect sensitivity to environmental risk factors, making some people more susceptible (Plomin et al., 1977). They can also, conversely, be …

1 day ago · It is increasingly recognized that genetic effects on complex traits and diseases are shaped by environmental context. Biobanks that measure diverse environmental exposures alongside …

6 days ago · The research, published in Genome Biology, set out to identify gene–environment interactions that influence human traits and, ultimately, disease risk. While many genetic studies …

Traits come from genes, environment, and their interaction. Learn how DNA, epigenetics, and mutations shape what living things look and act like.

Apr 4, 2024 · Here, we provide a detailed explanation of five “phenomena,” or data-generating mechanisms, that can lead to nonzero interaction estimates, as well as a discussion of specific …